Background: Gamma Glutamy l Transferase (GGT) is involved in pathogenesis of various cardiovascular diseases. Aim: To assess serum GGT level in predicting significant CAD (Coronary Artery Disease).

Methods: 200 patients undergoing CAG were studied. Serum GGT level was compared between normal/insignificant CAD Group (Group 1) and significant CAD Group (Group 2). Comparison between various subgroups was done.

Results: Mean age of study population was 57.63 ± 10.78 years. Mean of serum GGT level in Group 1 was 31.61 ± 20.17 and in Group 2 was 39.48 ± 22.91. (p = 0.004). Mean ± SD of SVD, DVD and TVD were 43.29 ± 24.05, 36.8 ± 20.47 and 39.06 ± 26.04 and were not statistically significant.

Conclusion: Serum GGT level can be used as a noninvasive biomarker to predict significant CAD.