Introduction: Middle ear surgeries as such are associated with PONV and when inhaled anesthetics are used in these surgeries, the incidence of PONV might vary. Achieving a more effective outcome with respect to PONV will become increasingly important in the future as a result of increasing pressure to decrease discharge times. Aims: To compare the intra-operative hemodynamic parameters along with postoperative nausea and vomiting with Desflurane and Sevoflurane in Middle Ear Surgeries. Materials and methods: The present study was a prospective, randomized, comparative clinical study, was conducted in patients scheduled to undergo elective middle ear surgeries in 60 patients, planned for elective middle ear surgeries under general anesthesia. Patients between the age of 12 and 60 are selected for the study comprising of both sexes. They are divided into 2 groups randomly, Group S (Sevoflurane) and Group D (Desflurane); 30 patients in each group. Results: The difference in average preoperative systolic, diastolic blood pressure, heart rate was statistically not significant when compared in both groups. There was no statistically significant difference (p > 0.05) between the two groups with respect to PONV as Fisher's exact test statistic value is 1. Conclusion: No significant difference was found in terms of intra-operative hemodynamics and postoperative nausea and vomiting in patients receiving general anesthesia with sevoflurane and desflurane as inhalational agents for Middle ear surgeries.