Propofol is one of the most commonly used induction agent. Pain on injection still remains a considerable concern for anaesthesiologist. The aim of the study was to assess the efficacy of granisetron HCL and ligocaine HCL to alleviate the pain on propofol injection. Methods: Fifty patients aged 18-50 years, ASA grade 1-2, posted for elective surgeries under general anaesthesia were randomly divided into two groups. Group G received 2 ml (1 mg/ml) granisetron while group X received 2 ml (2%) ligocaine intravenously before propofol injection. Manual venous occlusion was done for 1 minute after pre-treatment drug. 2 ml of total calculated dose of propofol was given over a period of 4 seconds. Patients were asked about the pain on injection with use of verbal rating score chart after 15 seconds. HR, SBP, DBP, SpO2 was measured 0, 1, 3 minute after propofol injection. Results: HR, SBP and DBP were significantly raised in granisetron group as compared to lidocaine group. Average pain score in group G was 2.1 while in group X it was only 0.8, which was statistically significant. (p<0.05). Conclusion: We conclude that lignocaine HCL is better than granisetron for alleviating pain after propofol induction.