Background: Laparoscopy is now preferred because of various advantages such as reduced post operative pain, faster recovery and shorter hospital stays. It is associated with pneumoperitoneum, variations in patient positioning, and stress response leading to various haemodynamic changes. Various anaesthetic interventions like epidural, combined epidural and general anaesthesia, and pharmacologic interventions like nitroglycerine, esmolol have been used. Aims and objectives: To evaluate and compare the effects of oral clonidine v/s placebo in obtunding haemodynamic response to laryngoscopy, intubation and pneumoperitoneum in patients undergoing laparoscopic cholecystectomy. Postoperative sedation and other side effects were also observed. Materials and Methods: Patients were randomized into two groups­ Group C: 150 mcg of clonidine. Group P: Vitamin – C tablets 500mg, each receiving drugs orally 90 minutes before induction. Effect of oral clonidine in obtunding hemodynamic response and post operative sedation were monitored. Result: No significant difference was observed in mean age, gender and preoperative vital parameters (p>0.05). Significant difference in Heart rate, SBP, DBP, MAP after intubation, during incision, starting and release of pneumoperitoneum between the two Groups (p<0.05). Post­operatively patients in group C were sedated but aurosable as compared to Group P. Conclusion: Premedication with 150 mcg of oral clonidine is safe and improves perioperative haemodynamic stability and reduces postoperative sedation, nausea and vomiting in patients undergoing laparoscopic cholecystectomy.