Diabetes is a global epidemic and one of the most leading complications of diabetes is peripheral europathy. Recent research and clinical practice focus is on symptomatic or painful diabetic peripheral neuropathy (PDPN). The objective of this review is to throw light on commonly used and well-established drugs and pharmacotherapy options in PDPN patients. The various drugs reported in controlled clinical trials in MEDLINE were searched independently and 118 suitable trials were identified. The selected studies are grouped under each drug and the drugs are described in alphabetical order in the review. The pharmacotherapy for PDPN patients includes Duloxetine (24 studies), Pregabalin (10 studies), capsaicin 6 studies), Oxcarbazepine (6 studies) and so on. The total number of drugs reviewed under pharmacotherapy for PDPN was 44. The review would facilitate clinicians and stakeholders to understand the established drug therapy options for symptomatic management of patients with painful diabetic peripheral neuropathy, and also facilitate researchers to develop better drugs in future.   

Key words: drug therapy, diabetic neuropathy, neuropathic pain, management.