AbstractIntroduction: The adjuvant therapeutic radiation therapy (RT) results in the development of cranial neoplasms, though is a rare entity but a serious complication.Tthe most common form of radiationinduced neoplasm is the radiation induced meningiomas. These are the late complications in patients who have received adjuvant radiation therapy for brain tumors. In 1953, Mann, et. al. first described a 4yearold girl who was treated with 65 Gy for an optic nerve glioma developed a meningioma in the irradiated field which eventually became malignant. The most common form of the RIBT is the Meningioma as reported in the literature [3]. Radiationinduced meningiomas developing after the surgical excision of medulloblastoma are seen very rarely.
Case Report: A 13yearold male patient presented with left frontal meningioma which developed after 9 years from receiving adjuvant radiation therapy for medulloblastoma. Surgical resection and RT was applied at the age of 4 for medulloblastoma. At age of 13, the patient had features of raised ICP (Intra Cranial Pressure). A neurological examination was normal. Magnetic resonance imaging demonstrated a left frontal mass. The patient underwent left frontal craniotomy and the mass removed totally. Histopathological examination revealed a meningotheliomatous meningioma.
Conclusion: The adjuvant RT given post operatively for medulloblastoma resulted in the cytological changes of tumor cells. All the cases of pediatric malignancies and those particularly exposed to adjuvant radiation therapy are advised for followup for a longer period of time as it is crucial for the early detection of the radiation induced tumors and it should be considered as a part of the effective therapy of the primary disease.
Keywords: Radiation Induced Meningiomas (RIM); Sporadic Meningiomas; Medulloblastoma.