Introduction: Administration of local anesthetics into the pleural space provides rapid onset and long duration of analgesia upper abdomen surgeries without respiratory depression as seen with opioids.in this study we attempt to find the efficacy of interpleural analgesia in reducing post operative pain and parenteral analgesic requirement in patients undergoing upper abdominal surgery. Aim: To analyze the efficacy of interpleural analgesia in reducing post operative pain and parenteral analgesic requirement in patients undergoing upper abdominal surgery. Materials and Methods: After ethics committee approval and written informed consent 36 patients undergoing elective upper abdominal surgeries were selected randomly based on computer generated random numbers. General anaesthesia administered as per routine in our hospital. When the surgery was over the patients divided into two trearment groups of 18 patients. 1. Pleural analgesia (bupivacaine) combined with Parenteral analgesics (Pentazocine). Forty milliliters of Injection bupivacaine 0.25%via intrapleural catheter. 2. Parenteral analgesics alone. (Pentazocine). Results: Consumption of pentazocine were higher in control group than in pleural group, for Day 1(P < 0.001), Day 2 (P < 0.01) and Day1 + 2 (P <0.001) Mean pain scores were significantly reduced 30 min after IP instillation of bupivacaine 0.25 % compared to control group. Conclusion: It is concluded from this study that intermittent interpleural analgesia with bupivacaine was more effective than intermittent intramuscular administration of pentazocine alone.