Background: The pathological bone lesions are wide array from inflammatory to neoplastic conditions. The X-ray helps in exact location of lesion, but most often times it is very difficult to diagnose and differentiate. This problem can be overcome with the help of histopathological study. Objective: To study histopathological spectrum of bone lesions and correlate them with age, gender, site and type of lesion. Materials and Methods: The present Descriptive, Cross sectional study was carried out at Dr. PSIMS and RF from December 2014 to November 2016. A total of 82 bone biopsies were received. Histopathological examination of the bone specimens was performed after detailed clinical and radiological examination. After fixation, decalcification, processing and H&E staining, histopathological diagnosis was made. This study was approved by the institutional ethical committee. Result: Total 82 cases of bone biopsies were analyzed. Out of 82 bone lesions 65(79.3%) were Non-neoplastic, 16(19.5%) cases were Neoplastic and 1 (1.2%) case was inadequate for diagnostic evaluation. Benign bone lesions were more preponderant than malignant with 13(15.5%) and 3(3.7%) cases respectively. Chronic osteomyelitis was the most common non- neoplastic lesion. Osteochondroma and Osteosarcoma were most common benign and malignant lesions respectively. Tibia was most common bone involved in benign lesions and femur for malignant lesions. Maximum number of bone lesions present in the age group between 40-60 years, with male preponderance. Conclusion: An integrated use of clinical, radiological, and histopathological findings were recommended to increase accuracy of diagnosis and for better management of the patient

Keywords: Bone Lesions; Osteochondroma; Chronic Osteomyelitis; Histopathology; Osteosarcoma; Chondrosarcoma.