Although histological study is one of the most valuable means of diagnosis in dermatology, it has its own limitations. Often no definitive diagnosis can be made. The reason for this is often very few dermatoses, aside from tumors are regularly associated with a diagnostic histopathological picture. Materials and Methods: This study is a prospective cross sectional study done at Adichunchanagiri Medical College, BG Nagar, Karnataka, India, over a period of 2 years from March 2015 to 2017 march comprising of 120 cases of papular lesions of the skin. Results: 120 cases of papular lesions were divided into 11 groups and subgroups. The infectious disease constituted the majority of cases and degenerative disease and tumors of vascular tissue was the least. Conclusion: From this study is that histopathological diagnosis although is one of the valuable means of diagnosis in dermatology, it has been shown to have its own limitations as often no differential diagnosis is made. In many instances the chief value of histopathology lies in corroborating the clinical diagnosis or in ruling out the possible diseases. Inspite of that histopathology has a major investigative role in papular lesions of the skin.

Keywords: Papular Lesions; Inflammation; Diagnosis.