AbstractAcute appendicitis is the commonest cause of “Acute abdomen”. Appendicectomy is the most frequently performed emergency operation. The aim of this study is to determine the diagnostic accuracy of the above markers individually in acute and perforated appendicitis as well as their value in excluding the condition. The study is a prospective study. This study was performed on 100 patients who have been clinically diagnosed of having acute appendicitis and who were posted for emergency appendicectomy have been clinically and radiologically diagnosed of acute appendicitis. Out of 100 patients, 52 were males and 48 are females, so male predominance is seen in the present study. Appendicitis is common in the age group of 21-30 years and <20 years in this study. Appendicitis reaches its peak incidence in the teens and early 20’s. Clinical diagnosis was found to be correct in 88% of cases and hence the rate of negative laprotomies for acute appendicitis in our study is 12%. Patients presenting with elevated levels of serum bilirubin in the context of right iliac fossa pain warrant early surgical intervention. The diagnosis of acute appendicitis, however remains multifactorial and such test simply help to guide the surgeon in the decision making process.