Background: Pancytopenia means decrease in all three cell lines .It is the striking feature of many illnesses ranging from megaloblastic anaemia to leukaemias. The underlying pathology of pancytopenia will determine the management and prognosis. Objective: To identify the various etiologies of Pancytopenia. Materials and Methods: The present study was undertaken at BRIMS Bidar. Results: 100 cases were studied, 57 males and 43 females with age ranging from 3 yrs to 90 yrs .Most of the cases presented with generalized weakness, followed by pallor, hepatosplenomegaly and bleeding manifestations. Conclusion: The present study were helpful in understanding the various causes of diseases process with bone marrow aspiration done in few of the pancytopenic patients along with support of biochemical investigations which were helpful in planning further investigations and management.

Keywords: Pancytopenia; Bone Marrow Aspiration; Megaloblastic Anaemia; Leukaemia.