Advertisement!
Author Information Pack
Editorial Board
Submit article
Special Issue
Editor's selection process
Join as Reviewer/Editor
List of Reviewer
Indexing Information
Most popular articles
Purchase Single Articles
Archive
Free Online Access
Current Issue
Recommend this journal to your library
Advertiser
Accepted Articles
Search Articles
Email Alerts
FAQ
Contact Us
Indian Journal of Anesthesia and Analgesia

Volume  4, Issue 2, April - June 2017, Pages 537-541
 

Original Article

Effect of Auto-Co-Induction of Propofol on Total Induction Dose and Haemodynamics

C.B. Sridhar*, Sulochana Dash**, Shoba K.***

*Professor **Associate Professor, Dept of Anaesthesia ***Professor, Dept of Otorhinolaryngology, Saveetha Medical College, Chennai, Tamil Nadu.

Choose an option to locate / access this Article:
90 days Access
Check if you have access through your login credentials.        PDF      |
|

Open Access: View PDF

DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.4217.29

Abstract

Introduction: Rapid induction with propofol causes fall in arterial pressure and tachycardia.Our study aims at comparing the hemodynamic changes between rapid dose and priming dose, measure propofol requirement and evaluate complications between the two groups. Materials and Methods: Hundred consecutive patients posted for elective surgery under general anaesthesia with endotracheal intubation were randomly divided into two groups of 50 patients each (Group I and II). Group I (priming dose) received 20% of the total calculated dose of inj. Propofol (2 mg/kg) and 30 seconds later the remaining calculated dose of propofol was injected at a rate of 30 mg/10 seconds till the loss of eyelash reflex and group II(rapid induction dose) were injected propofol at a speed of 30 mg/ 10sec until the loss of eyelash reflex. Heart rate, arterial pressure, total induction dose and complications were recorded. Results: The mean induction dose of propofol was 109.60 in group II and 90.84 in group I.The mean heart rate were higher and mean arterial blood pressure were lower in control group at one and three minute after induction compared to study group. It was also observed that 50% in  control group and 68% in study group had developed various complications. Discussion: In our study priming dose reduced the total induction dose requirement of propofol by 18%. There were lesser hemodynamic fluctuations with priming dose. Apnea and fasiculations were more in priming group. Conclusion: Priming principle requires lesser dose of propofol and prevents hemodynamic fluctuations caused due to propofol.
 


Keywords : Auto-coInduction; Priming Dose; Rapid Dose; Blood Pressure; Heart Rate.
Corresponding Author : Shoba K., 68/11B, GNT Road, Sembulivarum, Chennai-600067.