Abstract Background: LMA is a device commonly used in the practice of anaesthesia . Insertion of LMA however needs obtundation of upper airway reflexes and relaxation. Aim: Conditions for insertion of LMA, haemodynamic stability and respiratory depression following induction with Propofol was compared with Thiopentone preceded by topical Lignocaine spray. Methodology: Sixty ASA I and II patients undergoing short elective surgical procedures like breast surgeries, minor plastic surgeries, short surgical procedures of upper limb and hernia repair, in patients aged between 1660yrs, were included in the study. They were randomly allocated into two groups of thirty each. The presence of coughing, gagging, laryngospasm, head movements, limb movements and Jaw relaxation during LMA insertion were noted. Number of attempts for insertion and postoperative sore throat were also assessed. Haemodynamic parameters and respiratory depression (presence or absence of apnea) were also observed. Results: Adequate jaw relaxation was significantly better in Propofol group than Thiopentone with topical lignocaine group (100% versus 70%). Incidence of apnea, fall in BP and tachycardia was significantly more with Propofol than Thiopentone with topical lignocaine group (p<0.05). Conclusion: Thiopentone preceded by topical lignocaine spray could be considered for induction prior to LMA insertion, in view of significant haemodynamic fluctuations and respiratory depression caused by Propofol.