Spinal manipulation is most rapidly evolving evidence-informed technique and hence it is essential to imply high quality evidence in terms of systematic reviews and/or meta-analyses for this highly popular therapeutic technique. The objective of this short review was to provide an update of systematic reviews and/or meta-analyses on spinal manipulation through a preliminary search of PubMed database. The ten identified systematic reviews were on adverse events, and of them four were on spinal manipulation and six were on cervical spinal manipulation. Majority of systematic reviews on spinal manipulation reported on cervical spine, since the presumed risks due to manipulation of the cervical spine are much more than that of the lumbar spine due to the related neurovascular structures and hence most studies on adverse events concentrated on cervical spinal manipulation.