Objective: Our objective was to assess the clinical outcomes (benefits and drawbacks) and change in level of inflammatory parameter IL-6 in patients undergoing single incision laparoscopic cholecystectomy and comparison with classical four port laparoscopic cholecystectomy. Methods: Between September 2013 to July 2015 a prospective randomised study was conducted. Sixty patients were included in the study and they underwent elective gall bladder removal by applying the laparoscopic technique. All the patients were divided into two groups. Single incision laparoscopic cholecystectomy (group I) and four port laparoscopic cholecystectomy (group II). Outcome Measures included operative time, pain intensity post operatively and consumption of pain killers, hospital stay, need for conversion, complications, cosmetic effects and change in the level of serum Interleukin-6 post operatively as an inflammatory marker. Results: Mean operating time in group I was 71 min and group II 39 min. Intensity of pain evaluated by using the VAS at 8 hours after surgery in group I was 6.5 and in group II 6.5, whereas after 7 days in group I it was 2.7 and in group II 3.6. The pain killer requirement in group I was smaller than group II. Mean hospital stay after the operation in group I was 2.2 days and in group II 2.0 days. There were 2 conversions in group I and 1 in group II. Cosmesis evaluated by a 0 to 10 scoring system which showed better cosmesis in group I patients. Change in the serum level of IL-6 post operatively was more in case of multiport laparoscopic choecystectomy than single incision laparoscopic cholecystectomy. Conclusion: Single incision laparoscopic cholecystectomy is a safe and feasible procedure which has a better cosmesis and faster recovery.