The present study was conducted with the aim to assess the safety and efficacy of misoprostol alone and misoprostol with simultaneous mifepristone for second trimester termination of pregnancy. Material & Methods: The study was conducted on 160 cases, divided in two groups of 80 cases each. In the study group 200 mg mifepristone and 200 mg misoprostol given together on admission followed by misoprostol every 3 hrs upto a maximum of 8 doses or until the abortion occurs, whichever occurs early. In the control group only misoprostol was given in the same dose regime. If abortion did not occur within this duration it was considered failure of method. The results were analysed. Results: The success rate in first regimen was 98%. Mean induction abortion interval was significantly shorter in the study group, 8.62 ± 1.96 h as compared to 14.5 ± 3.01 h in the control group. The mean dose of the misoprostol required was significantly less in study group. The side effects like nausea,vomiting,fever,abdominal cramps,diarrhoea were observed more in control group (30%) in comparison to study group (12.1%). Conclusion: Mifepristone with simultaneous misoprostol is better than misoprostol alone and there is no need to wait for 24 hr after mifepristone for administration of misoprostol.