This study entitled “study to assess the effectiveness of instructional approach on knowledge regarding prevention and management of road traffic accident among adults in selected areas of Gonda”submitted in the year 2024.Aims: The objectives are to assess the knowledge level on prevention and management of road traffic accident among adults in selected areas of Gonda; to assess the effectiveness of instructional approach on knowledge regarding prevention and management of road traffic accident among adults in selected areas of Gonda; to determine the association between the knowledge with the socio-demographic variables.Hypothesis: There is a significant association between the level of knowledge with socio demographic variables. Design and setting: Quantitative approach quasi experimental one group pretest posttest design was used.Methods and materials: Simple random sampling technique was used to select 50 participants. Structured questionnaire was used to collect the data. Teaching program was conducted on prevention and management of Road traffic accident and the posttest was done on the 7th day. The results of this study revealed that there was a significant knowledge improvement (t=29.25, p<0.05) after the instructional approach.