AbstractContext: There is a lack of universally applicableand updated treatment protocol for retinoblastoma in India, which causes hurdles in the management of this childhood cancer. We have described the outcomes of subjects treated using our protocol (based on the International Classification of Retinoblastoma)that could be adopted for the management of retinoblastoma. Aim: The international classification of retinoblastoma defines the prognosis-based classification of subjects. The protocol followed at our institute is based on the ICR and the retinoblastoma outcomes for the last 5 years have been analysed and presented. Setting & Design: Tertiary care centre-based retrospective study. Methods and Material: Five-year records of the retinoblastoma patients treated using a standard ICR-based protocol were analysed for clinical profile, treatment delivered, and outcomes. Appropriate statistical tests were used for parametric/non-parametric data and categorical variables to compare the groups. Kaplan-Meier survival analysis was used to describe the survival probability. A p-value of 0.05 was considered significant. Results: There were 209 subjects and 251 retinoblastoma-affected eyes which were included and analysed in the study. The overall survival rate was 90.10% and 1, 2, 3 and, 5-year survival estimates were 96.6%, 94.9%, 92.2%, 88.3% respectively. Forty-two (16.73%) eyes with retinoblastoma were retained after local tumour control and 209 (83.27%) eyes needed enucleation. Conclusions: The retinoblastoma treatment protocol based on ICR has shown improvement in the outcomes at our centreanddefined the resources needed for the management of retinoblastoma.