Systemic diseases such as diabetes mellitus, rheumatoid arthritis (RA), and chronic kidney disease (CKD) often have musculoskeletal complications that significantly impact patients’ quality of life. These complications necessitate a multidisciplinary approach involving orthopedic surgeons and other specialists to ensure early recognition, intervention, and optimized patient care. An interdisciplinary approach enables the integration of systemic and musculoskeletal health strategies, leading to better patient outcomes. For instance, diabetes-related Charcot arthropathy and osteomyelitis require both orthopedic and endocrinology care, while RA demands immunosuppressive therapies alongside orthopedic interventions. CKD, due to disruptions in calcium and phosphate metabolism, increases fracture risks and requires nephrology and orthopedic collaboration. Emerging technologies such as telemedicine and precision medicine further support collaborative care. This article underscores the importance of interdisciplinary teamwork in addressing the musculoskeletal manifestations of systemic diseases.