Nanotechnology and stem cell therapy (SCT) have emerged as revolutionary approaches in musculoskeletal disorders, offering innovative solutions to complex disoders. Traditional orthopedic surgeries and pharmaceuticals often fall short in terms of long-term efficacy and recovery time. Nanotechnology and stem cell therapy present more advanced, targeted, and minimally invasive alternative approach.  Nanotechnology involves the manipulation of materials at nanoscale to create systems that can deliver correct diagnosis, and treatment of musculoskeletal disorders. Nanomaterials, such as nanoparticles, nanotubes, and nanofibers, have depicted significant improvement and enhancement in bone regeration, drug delivery, and tissue repair. small size of nanoparticles allow them to integrate better with biological system, ensuring precision in delivering therapeutic agents to specific sites in order to minimizing their side effects. Interestigly, nanoscale scaffolds have been developed to promote bone and cartilage regeneration by mimicking the extracellular matrix (ECM) and supporting the growth of new tissues.  On the other hand, SCT uses undifferentiated cells with the ability to transform in to specific types, offering significant role in the treatment of damaged tendons, cartilage and bones. These stem cells can be guided more effectively to the target areas with the  combination of nanoparticles, increasing the success rate of treatments.