Opioid free anesthesia in Neurosurgery is an evolving concept in light of recent era. Classic convention of using opioid as a cornerstone for provision of analgesia during neurosurgeries is now being shaken off by the ongoing emerging evidence. The present case report aims to bring out the successful usage of opioid free anesthesia during aneurysm clipping surgery. We discuss in detail the various pros and cons including pitfalls in the literature review alongwith this case report.