Introduction: Intubation can sometimes be difficult in patients with lesions in the mouth floor. Ameloblastoma is a frequently encountered tumor of the maxillofacial area. An extensive lesion might occupy the floor of the mouth, prevent displacement of the tongue, limiting the space for inserting a laryngoscope blade and resulting in difficult intubation even with fiberoptic bronchoscopy. Ameloblastoma is a common neoplasm affecting the jaws. It is an aggressive benign tumor of epithelial origin. Ameloblastomas are recognized for their invasive growth and tendency to recur. Reconstruction procedures are usually prolonged and require meticulous attention to fluid replacement, blood loss and prevention of hypothermia. Hence they present a challenge to the anaesthesiologist.  Case Report: A 40-year-old woman weighing 36 kgs presented with pain and swelling in the right jaw/mandible that had existed for three years. Her past medical history was unremarkable. Upon airway examination, mouth opening was inadequate, restriction of head and neck movements was noted, CECT showed pneumocysts in C5, C6 and C7 vertebrae and showed a large expansile lytic lesion involving body of mandible and inferior aspect of rami bilaterally with cysts and solid components show heterogeneous post contrast enhancement with mass effect on adjacent structures.  The results of general and systemic examination were within normal limits. Two large bore 16G cannulas secured for proper fluid resuscitation intraoperatively, as mouth opening is inadequate and difficult bag and mask ventilation anticipated.  Planned for awake fibreoptic intubation, patient premedicated with Glycopyrrolate and Fentanyl. As expected patient had breathing difficulty during the procedure and laryngeal edema seen on fibreoptic, patient given Dexamethasone 8mg, preoxygenated with facemask for 10 minutes and opted for 6mm ID flexometallic ET tube fibreoptic intubation. Torniquet applied for 2 hours to left thigh to minimize blood loss for fibular graft patient developed hypotension after 8 hours of surgery PRBC and colloids transfused and resuscitated  with fluids as surgeons opted for tracheostomy in between, after 16 hours of surgery patient shifted to ICU for observation shifted back to ward.   Conclusion: Our case was anticipated difficult airway, planned for awake fibreoptic intubation,even though it was prepared, because of the tumor, airway edema present and all small size endo tracheal tube was used surgical airway was ruled out as tumor was big and was in midline.