Early onset neonatal sepsis (EONS) represents a significant source of morbidity and mortality among newborns, necessitating timely diagnosis and treatment. This review article explores the development and application of a calculator designed to aid in the early identification of EONS in neonates. The calculator integrates clinical risk factors, laboratory findings, and maternal history to provide risk stratification for infants at birth, thereby assisting healthcare professionals in making informed decisions regarding the need for empirical antibiotic therapy and further diagnostic evaluations. By reviewing relevant literature on EONS risk factors, current diagnostic protocols, and the utility of predictive modeling in neonatology, this article aims to highlight the importance of individualized assessment in managing at-risk newborns. Furthermore, we discuss the implications for clinical practice and potential areas for future research in improving outcomes for this vulnerable population.