The significance of soya beans in animal feed and human nutrition has prompted   extensive research into their protease inhibitors, particularly due to their impact on  digestion and growth inhibition. Despite initial assumptions linking trypsin inhibitors to
poor nutritive value, understanding their precise role has proven complex. This article  presents a comprehensive review of plant based protein digestibility, focusing on factors  influencing bioavailability and the effects of protease inhibitors such as Bowman-Birk
and Kunitz-type inhibitors. Drawing from recent literature, it explores the mechanisms underlying growth inhibition and pancreatic hypertrophy, shedding light on the  dynamic interplay between protease inhibitors and digestive physiology. Additionally,
it discusses the broader implications for human health and the potential of protease   inhibitors in shaping plant centric dietary patterns. Through a synthesis of experimental  findings, this review provides valuable insights into the intricate relationship between
protease inhibitors and plant protein digestibility, offering guidance for future research  and dietary practices.