Normal Blood Pressure (BP) is the key factor for sustaining a healthy life. BP variation is  related to daily life including body position, breathing rhythm, stress level, physical condition etc. Hypertension as well as Hypotension will lead to many complications in the healthy life of  the general as well as dialysis population. The prevalence of Hypertension in Urban communities  is higher than that in Rural communities. Complications of uncontrolled hypertension will affect various organs in our body as an acute or chronic effect. Factors affecting Hypertension  in the dialysis population slightly differ from the general populationdue to renal failure. It
is certainthat preventive measures or controlling measures of BP variation are only possible  when we can understand the normal physiology of BP as well as the factors which affect  BP maintenance in our body. This paper will help you to understand various aspects of BP  variation in general as well as the dialysis population.