Respondent Driven Sampling (RDS) is becoming a widely used method to sample hardto-reach populations, especially in Public Health and Social Science research. The purpose of  this systematic review is to present an overall view of RDS methodology, its applications in  different areas as well as the difficulties faced when implementing it. A search of electronic  databases was conducted systematically to find relevant studies for synthesis that would  provide insight into the strengths, limitations and future directions of RDS.