AbstractPaget-Schroetter syndrome, also known as effort thrombosis, is a rare condition characterized by the development of a blood clot (deep vein thrombosis, DVT) in the deep veins of the upper extremity, particularly the subclavian or axillary veins. It typically affects young, healthy individuals, often athletes or those engaging in repetitive upper limb activities, leading to compression of these veins. Clinical presentation includes sudden onset of pain, swelling, and discoloration of the affected arm. Diagnosis is confirmed through imaging studies such as ultrasound, CT venography, or magnetic resonance imaging (MRI). Management includes anticoagulation therapy, thrombolysis, and sometimes surgical intervention to relieve venous compression. Early diagnosis and treatment are crucial to prevent complications such as pulmonary embolism or post-thrombotic syndrome.