Recent years have seen a significant increase in interest in innovative drug delivery systems because of their advantages over traditional medication administration methods. This work presents a novel method of drug delivery by discussing the idea of a herbal medication in transferosomes.Transferosomes are extremely pliable vesicles that have recently been presented as novel medication carriers. They have the ability to transport large molecules through intact mammalian skin. The use of lipid vesicles as a drug delivery method for skin therapy is still controversial, despite garnering more attention this year; most relevant papers emphasise the localization effect of liposomes, with the transport mechanisms mentioned in a few cases, depending on the formulation. A novel and cutting edge medication delivery technique called transferosomes has been created to get around the clarity issue and break through the skin barrier along the transcutaneous gradient. These are certain kinds of liposomes that have phosphatidylcholine water as an edge activator, or that contain it. Biocompatible and biodegradable properties are two advantages of transferosomes. It prevents the medicinal product from being broken down by metabolism.When coupled to generate transferosomes, both hydrophilic and hydrophobic compounds have a wider range of solubility. These carriers are extremely adaptable and excellent at holding a wide range of medications, regardless of their size, molecular weight, polarity, or form. Transferosomes have the ability to transport both high and low molecular weight drugs, including insulin, sex hormone, albumin, corticosteroids, and anti-cancer medicines. Many medications, including those used to treat cancer, atopic dermatitis, hypertension, anti-edema, analgesics, anti-inflammatory agents, and cutaneous leishmaniasis, exhibit activity in transferosomes.