AbstractThyrotoxicosis secondary to levothyroxine overdose presents multifaceted clinical dilemmas influenced by dosage, patient age, and psychiatric factors. Our case, involving a 32-year-old female with chronic hypothyroidism ingested a substantial amount of levothyroxine, highlights the potential severity of such incidents. While accidental poisoningismorecommoninpaediatricagegroup,our caseunderscores thesignificanceof adult cases, particularly those with underlying psychiatric conditions. Prompt recognition and intervention are paramount, given the risk of severe manifestations like thyroid storm. Treatment strategies, including symptom management and hormone elimination, facilitated the patient's recovery, emphasizing the importance of comprehensive multidimensional care and heightened clinical vigilance. This case underscores the need for tailored management approaches and multidisciplinary collaboration to optimize outcomes in cases of levothyroxine intoxication induced thyrotoxicosis.