Life skills are a set of human skills acquired via teaching or direct experience that are used to handle problems and questions commonly encountered in daily human life. Given this, a study was undertaken to assess the impact of life skills on the academic performance of nursing students studying at selected colleges, in Thrissur. The main objectives were to assess the existing life skills among nursing students, to assess the academic performance of the nursing students, to find out the relationship between life skills and academic performance among the nursing students, and to find out the association between life skills among the nursing students with their selected demographic variables. A correlational research design was used and the sample was 170 B.Sc. Nursing students. A total enumerative sampling technique was used. The data was collected using a Demographic profile, academic performance, and structured life skill assessment questionnaire. The study findings revealed that out of 170 students, 93 (55%) students had high levels of life skills whereas 77 (45%) students had moderate levels of life skills. No students had a low level of life skills. The in-depth analysis pinpointed that out of 170 students, 112 students (7%) had distinction, 112 students had first class, 6 students had second class and 40 students failed in the university exam. A positive correlation of 0.241 was noted between the level of life skill and academic performance among nursing students at the level of 0.05 level of significance this depicted that level of life skill is directly proportional to academic performance.