Background: Salivary glands, pivotal for oral health, present diagnostic complexities withdiverse pathologies, including neoplasms constituting 6% of head and neck tumors. FNAC proves to be a reliable and cost-effective diagnostic tool, proficient in discerning various salivary gland lesions.

Aims: This study aims to comprehensively explore the spectrum of salivary gland lesions within a tertiary care center, emphasizing FNAC precision.

Materials and Methods: This retrospective observational study, conducted at Dr. Shankarrao Chavan Government Medical College and Hospital, Nanded, from January 2021 to September
2023, aimed to comprehensively analyze 60 cases of suspected salivary gland lesions using FNAC.

Results: This study examined 60 salivary gland tumor cases, finding a balanced gender distribution (51.67% males, and 48.33% females). Prevalence peaked in ages 31-40 (25%). Parotid(50.00%) and submandibular (43.33%) glands were primary tumor sites. Chronic sialadenitis (30%) dominated non-neoplastic lesions. Pleomorphic Adenoma dominated benign cases
(21.67%), while Mucoepidermoid Carcinoma was the most common malignancy (3.33%). The sensitivity, specificity, and diagnostic accuracy for the neoplastic lesion were 75%, 100%, and
92.86% respectively.

Conclusion: This study enhances understanding of the demographic and pathological
landscape of salivary gland lesions highlighting the prevalence of non-neoplastic conditions