Volume
12, Issue 1, January – April 2023, Pages 21-23
Review Article
Wilson’s disease
Jancy J, Sheeja Sebastian
Assistant Professor, Medical Surgical Nursing, Seventh Day Adventist College of Nursing, Palakkad 679104, Kerala, India, 2 Assistant Professor, Jubilee Mission College of Nursing, Thrissur, Kerala 680005, India.
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Wilson's Disease is an autosomal-recessive disorder caused by mutation in the ATP7B gene which impairs copper excretion from the bile. Impaired copper transport and decrease copper secretion into bile which leads copper accumulation, first in the liver but ultimately in the brain and other tissues, produces clinical manifestations that may include hepatic, neurological, psychiatric and ophthalmological. Treatment is only palliative and intended to restore and maintain copper balance.