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DOI: DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.11422.1

Abstract

Introduction: Thrombocytopenia is defined as platelet count less than 150,000μl. There are various causes of thrombocytopenia’s include increased peripheral destruction of platelets, decreased production of platelet, increased splenic sequestration abnormal platelet production. Platelet indices including platelet count, mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT) & large platelet cell ratio (P-LCR) are helpful in evaluation of thrombocytopenias. Present study is evaluating this platelet indices by using five part cell counter. Method: It was an observational cross-sectional study conducted in Department of Pathology. All detected thrombocytopenia cases (platelet countless than 1.5 lakh/mm3) from CBC done by Five Part Cell Counter. Results: 150 cases of thrombocytopenia were included in our study. Majority of patients i.e 66.7% were in the age group of 15-49 yrs including males (52.7%) & females (47.3%). Infective conditions were found to be commonest cause of thrombocytopenia with 108 cases (72%), followed by 13(8.7%) anaemia cases, 8 (5.3%) ITP cases. The commonest cause of thrombocytopenia in was dengue with maximum cases of 74 (49.33%) out of 150 cases of thrombocytopenia. The mean MPV differed significantly (mean 9.5685 vs 8.5381) between two categories i.e in factious conditions vs all other conditions (except infectious), as indicated by a p-value of 0.02. The mean platelet distribution width (PDW) was significantly different [Mean ± SD (63.06 ± 23.63vs 44.00 ± 23.79)] between two categories i.e in factious conditions and all other conditions (except in fectious) as indicated by ap-value

<0.0001. The mean for parameter MPC showed significant difference [Mean ±SD (67.56±20.25 vs 53.30±27.57)] between two categories of dengue and other infectious disease with a p-value of 0.033 by using t-test for in dependent variable. The mean P-LCR was significantly higher (0.01 ± 0.01) in infectious condition as compared to non infectious category (0.004±0.008), as indicated by p-value of 0.007. The mean MP Md if fered significantly between two categories of infectious vs non infectious conditions as indicated by a p-value of 0.03. Conclusion: Newer platelet parameters are being studied so as to ease the prognosis and diagnosis of patients. These parameters are easily available in five part hematological analyser. Parameters like MPV, PDW, MPC, P-LCR & MPM show significant statistical value, thus aiding in diagnosing various causes of thrombocytopenia. PDW & MPM can determine the hypoproductive causes of thrombocytopenia, thus can be utilized for deciding the need of platelet transfusion.>

Keywords : Platelet parameters; Thrombocytopenia.

Corresponding Author : Sadhana Mahore Professor, Department of Pathology, NKP Salve Insititute of Medical Sciences and Research Centre, Digdoh Hills, Nagpur 440019, Maharashtra, India.devenmahore@gmail.com