Background of the study: The COVID-19 pandemic is ruined the world in all the aspects such as economical, health and education. The peoples were worried about the diseases, had the anxiety and fear about the disease condition and the peoples were having curious about the COVID-19 vaccine, when it will be available, where it will be available and what will be the cost and what are the side effects of COVID-19 vaccination and what efficacy of COVID-19. So this study was undertaken to assess the knowledge and perception of peoples regarding COVID-19 vaccination. Objectives: To assess the level of knowledge and perception about COVID-19 vaccine among peoples of selected society and to find the association between the levels of knowledge with selected demographic variables and to prepare the information booklet. Methodology: The quantitative research approach with descriptive research design was used. The total 100 samples were selected by purposive sampling technique. The self-administered structured knowledge questionnaires were used to assess the knowledge and perception scale was used. The data was analyzed by descriptive and inferential statistics. Results: The results shown that out of 100 samples 05(05%) were had inadequate knowledge, 74(74%) had a moderate adequate knowledge and 21(21%) had adequate knowledge regarding the COVID-19 vaccination. The overall mean percentage of knowledge was 61.90% with mean and SD of 18.57±3.36. The mean percentage score of perception was 81.15% with mean and SD of 16.23±2.35. The majority 63 (63%) of the samples had positive perception for acceptance of the COVID-19 vaccination, 29(29%) were had negative perception and 08 (08%) were had neutral perception regarding COVID-19 vaccination. Conclusion: The study concludes that the majority of the samples had moderately adequate knowledge and positive perception. There in need for further study to assess the attitudes of the peoples. Keywords: Knowledge; Perception; COVID-19 Vaccine; Peoples.