AbstractRegional anaesthesia is the preferred technique over general anaesthesia due to its overall fewer side effects. Cervical Epidural Anaesthesia (CEA) has been an upcoming technique for the past few years which provides safe and reliable anaesthesia for upper limb surgery. Objective: To compare the efficacy and safety of cervical epidural blockade with 0.5% Ropivacaine and 0.5% Levobupivacaine in upper extremity surgeries. Methods and Material: 50 patients were divided into two groups:- Group R: CEA block will be given with an Injection of Ropivacaine 10 ml (0.5%). Group L: CEA block will be given with an Injection of Levobupivacaine 10 ml (0.5%). Assessment of sensory and motor blockade was done in terms of onset and duration. Perioperative complications were recorded and managed accordingly. Results: The onset of sensory block with levobupivacaine was (6.28 ± 1.75min) and with ropivacaine was (5.56 ± 1.62 min) (p>0.05). The mean duration of sensory blockade was longer with levobupivacaine (296 ± 31.46 min) than with ropivacaine (192 ± 21.07 min). The mean time of onset of motor blockade(9.52±2.04 min) was shorter and duration (219 ± 31.74 min) was longer with Levobupivacaine than Ropivacaine (14.2 ± 3.75 min) and (165 ± 25.45 min) respectively. Postoperative Visual Analogue Score was higher in Ropivacaine. The mean time of duration of analgesia was longer in Levobupivacaine (315.6 ± 48.08 min). Conclusions: In an equal dose, Levobupivacaine has a faster onset (sensory and motor block) and longer duration (motor block and analgesia) as compared to Ropivacaine.