Introduction: Acute pancreatitis is one of the commonest conditions that presents as a surgical emergency worldwide. Aim: The aim of the study was to compare BISAP scorings and serum levels of C-reactive protein in predicting severity of acute pancreatitis. Materials and methods: Thirty patients got admitted from November 2012 to April 2014 in our hospital with acute pancreatitis were included in the study. C-reactive protein evaluated along with BISAP score at the time of admission. Patients assessed for severity by comparing both. Statistical analysis done by using Fischer's exact test, chi-square test and student t-test. Results: 23.3% of patients had a BISAP score of 3, rest had a score of 1 or 2. 66.7% of patients had an elevated CRP. An elevated CRP level and an increased BISAP score was found to have a statistically significant relation (p = 0.009 and p = 0.0002 respectively) to length of patient’s stay in hospital and hence the severity. BISAP and CRP levels had a positive correlation with a p-value of 0.064. Here, we found that BISAP scores had a statistically significant relationship with ICU stay (p-value: 0.014) Conclusion: In conclusion, we found that BISAP is a better predictor of severity of acute pancreatitis compared to CRP levels. It is a useful means of predicting severity in acute pancreatitis. Larger studies will be needed to further consolidate our findings, but it is safe to say that BISAP has the advantage of simplicity and speed over more traditional scoring systems. Keywords: Acute pancreatitis; Bisap scoring; C-reactive protein; Hospital stay.