Background and Aims: The present clinical study was conducted to evaluate the onset of analgesia, degree of sensory and motor blockades, duration of analgesia and complications between Levobupivacaine and Levobupivacaine with Dexmeditomidine in USG guided axillary brachial plexus block. Methods: The study was conducted on 60 ASA 1 and 11 patients of either sex posted for various elective or emergency surgeries of the upper limb involving elbow, forearm and hand surgeries. The subjects were divided into two groups, Group A receiving axillary brachial plexus block with 0.5% Levobupivacaine alone and Group B receiving Levobupivacaine with Dexmeditomidine 1 μg/kg. Results: The onset of sensory and motor blockades were quicker in Group B compared to Group A. Both these findings were statistically significant. Both the duration of sensory and motor blockades were longer in Group B compared to Group A which were statistically significant. Time taken for starting of regression was more in Group B compared to Group A but this finding was not statistically different. All other parameters related to duration of anesthesia including time taken for full motor and sensory recovery were longer in Group B compared to Group A. There were statistically significant differences in the duration of complete analgesia, duration of effective analgesia and time of first pain medication were longer in Group B compared to Group A. Conclusion: The onset, quality, intensity of sensory and motor blockades and the duration of analgesia is both clinically and statistically significantly prolonged in Levobupivacaine with Dexmeditomidine group.