Osteoporosis : Weak Bone Disease
Editor(s)/Author:
Dr. Dondeti Uday Kumar & Dr. R. B. Uppin
Available
2022-07-01
Dr. Dondeti Uday Kumar & Dr. R. B. Uppin
Available
2022-07-01
Osteoporosis is considered as a major growing global health care problem, especially with increasing life survival the aging society is at risk. In US, Osteoporosis is a major health problem affecting more than 10 million adults, estimating to more than 50% cost involved in annual fractures by 2025. It is known that Osteoporosis related mortality and morbidity is huge, amounting to almost 17 billion USD in 2005 itself. Similar observations were made in Australian Population with life time risk of osteoporotic fractures for women and men more than 60 years of age being 60% & 30% respectively.
Till recently, osteoporosis was considered a disease mainly of the developed countries. But now it is becoming a major problem even in the developing countries. It is predicted that the Asian countries alone would contribute to majority of the hip fractures when compared to rest of the world. More than 4.5 million women above the age of 60 years suffered fracture spine and more than 250,000 people had suffered from hip fracture per year due to osteoporosis. This causes severe compromise on quality of life. The life time risk of any osteoporosis fracture is 40% - 50% for women and 13% to 22% men. Hence it is a common disease affecting both older women and significant number of older men. In India, the magnitude of the problem is huge, affecting a large population, to the tune of about 50 million individuals. Today, in India the impact of this disease is comparable to if not more than cardiovascular disease or malignancy and thus needs to be addressed to urgently. Osteoporosis is a hidden public health concern requiring the attention of treating physicians, the health care system and the government for having a policy for early identification and management.
Osteoporosis is a disease of loss of bone mass. Early detection is important. But sadly, it is diagnosed only when fractures occur, similar to diagnosing hypertension after a myocardial infection or stroke. There is a need to have good screening techniques such as use of Bone Marrow Density or Dual Energy X- ray absorptiometry (DXA) etc. There is a need also to understand associated risk factors and to look at preventive measures such as early calcium supplementation, diet etc., to develop a health care policy to address this problem.
Foreword v
Preface vii
Acknowledgement viii
Chapter 1: Introduction 1
Chapter 2: Osteoporosis – Current Scenario in India 2
Chapter 3: Epidemiology of Osteoporosis 3
Chapter 4: Epidemiology of Fracture 4
Chapter 5: Economic Impact 5
Chapter 6: Factors That Influences Bone Strength 8
Chapter 7: Pathophysiology 18
Chapter 8: Causes of Osteoporosis 20
Chapter 9: Role of Homocystiene in Osteoporosis 22
Chapter 10: Clinical Manifestations 27
Chapter 11: Diagnostic Techniques 30
Chapter 12: Medical Management Osteoprosis 37
Chapter 13: Recent Advances in the Genetics of Osteoporotic Fractures 48
Chapter 14: Surgical Management of Osteoporosis Goals 52
Chapter 15: Osteoporosis in Childhood 58
Chapter 16: Osteoporosis after Solid Organ Transplantation 64
Chapter 17: Epidemiology of Osteoporosis in Rheumatic Diseases 78
Chapter 18: Systemic Lupus Erythematosus 83
Chapter 19: Exercise and the Prevention of Bone Fragility 86
Chapter 20: Osteoporosis - Future Trends 92
References 95
Osteoporosis : Weak Bone Disease