20 million people are experiencing various work related musculoskeletal disorders (WRMSD) around the world. These are group of painful disorders of muscles, tendons, and nerves, which occurs as a result of frequent or repetitive activities with awkward postures. Software professionals who usually adopt an awkward posture are more prone to develop WRMSD. Evidence suggested that long and extended working hours and rate of disorders are significantly correlated. This study aims to identify the prevalence of various WRMSD in software professionals who works in an IT industry. 400 software professionals were selected through convenient sampling method with descriptive study design. Nordic musculoskeletal questionnaire was given to all the participants. Data was evaluated and analyzed using SPSS software. The result findings shows that low back pain ranks first among the overall WRMSD and spine related problems are most common than peripheral extremities.